Longevity News Blog

I have the world's slowest speed of aging: 0.48 Breaking the 0.5 barrier. This means: + My birthday now happens every 2 years + I am #1 out of 5,677 global Rejuvenation Olympics competitors + My three test average: 0.54This new biological aging measurement science has begun nipping at the heels of the best predictors of all-cause morality. What is the Rejuvenation Olympics? When I started Blueprint, people didn’t know what category to place me so they’d blurt out words like vampire, Patrick Bateman, techbro, f*#@ face, biohacker, Prometheus, Dorian Grey, and more. It was clear that we needed a new category to define what I was doing so I started referring to myself as a “professional rejuvenation athlete”. When LeBron James eats and sleeps well, and then sets records, we praise him. When I did the same, hate rained. Understanding rejuvenation as a sport helps confer some respect and formality to the practice. With this framework, I created the Rejuvenation Olympics. A leaderboard for people who want to compete on their speed of aging, or rather the slowness thereof. Blueprint, Don’t Die and the Rejuvenation Olympics I was doing two things with this. First, up until I started Project Blueprint and Don’t Die, health influencers and health fads were primarily storytelling-based and anecdotal. What was missing: rigorous science, measurement and data. When health decisions are managed by storytelling, it’s hard to know what to do as you never really know what does or doesn’t work and who is or isn’t telling the truth. This led people to be very confused and feel paralyzed. This inspired my project to become the most scientifically rigorous and quantifiable of all time. I became the most biologically measured person in human history. If the goal is don’t die, we need robust, science based systems, with quantifiable results. We built Blueprint on population level scientific evidence. So it’s not an accurate criticism that Blueprint is based upon my biomarkers. Blueprint is for everyone. Yes, each person’s Blueprint can further be customized to your individual needs however the core protocol is applicable to everyone of all ages. The Rejuvenation Olympics set a level playing field for anyone who wanted to compete in health and wellness. Humans love points, status and leaderboards, and these are essential for any competitive sport.  Why your Speed of Aging is important I chose the speed of aging metric because of the robustness and reliability of the signal it measures. DNA methylation is a whole-body health marker that integrates thousands of biochemical cues into a measurable signal. The speed of aging algorithm distills this into a single number: an individual’s PACE score. In just a few years, this new biological aging measurement technology has begun nipping at the heels of the best predictors of all-cause morality. And it’s an easy finger prick at home. When talking about health and wellness, people can compare markers such as blood glucose, hormones, cholesterol and others. However, each of those are narrow in scope. DNA Methylation, and specifically the clock PACE, is a comprehensive assessment of one’s health.  So I created a new professional sport, gave it a name and rules and created a competition. As you might expect, people are really into it. Are you genetically gifted? From speaking to others on the leaderboard, I’ve learned that some people naturally (genetically) have a very low speed of aging. This makes intuitive sense based upon our life experience. Sometimes people do nothing for their health and are in perfect health. I personally met someone in the top 10 who was fairly close to me in his speed of aging and guess what he does for his health? Nothing. Meanwhile, lowering my speed of aging is a primary focus of my life. He is genetically gifted. I am not. However, even though I’m not genetically gifted, it is interesting that through methodical hard work, one can meaningfully slow down their speed of aging, even outperforming all the genetically gifted ones. When gene editing comes online, perhaps lowering our speed of aging will be a simple fix. Or, maybe it will even be a pill. Until then, I’ve loved playing this game of trying to understand the science, design evidence based protocols, and then execute with precision. The Rejuvenation Olympics has also been incredibly helpful for the entire health community, helping everyone understand what things increase and decrease one’s speed of aging. I’ll post more on this soon. How to compete in the Rejuvenation Olympics: 1. Get a Blueprint Speed of Aging Test. 2. When registering your test, you’ll have the option to participate in the leaderboard. 3. You need three tests to have a “verified” ranking on the leaderboard, and the tests need to be within the previous two years. Your best 3 test results within 2 years will be displayed, allowing for experimentation with various interventions and protocols while not punishing you for the learning process. Be well,Bryan

Want to learn your biological age? And do so using free tests? We’ve got you. Here are 7 free Bioage Fitness tests designed by the Blueprint clinical team that you can do at home. How to complete the Bioage Fitness tests:1: Download the Don’t Die App2: On your profile, go to ‘Measurements’3: Click on the + next to ‘Capabilities’4: Select the fitness assessment you will complete5: You can view the instructions for the fitness assessment in the app. These instructions are also included in this article.6: Enter your results in the Don’t Die App to receive your biological age Bioage Fitness Test Instructions: 1. Continuous Push-UpsObjective: Measure upper body strength and endurance.Goal: Perform as many push-ups as you can without res Instructions: Lie face down on the floor with hands placed slightly wider t\an shoulder-width apart, elbows fully extended. Lower your body until your chest touches the floor, keeping your body in a straight line from head to heels. Note - don’t round your back! Push back up to the starting position. This counts as one push-up. Perform as many push-ups as you can without rest (considered to be holding at the top 3 seconds), maintaining proper form. Record the number of push-ups completed. 2. Mobility Test: Sit Rise Test Objective: Assess flexibility, strength, and balance.Goal: Sit and rise without using your hands, knees, forearms, or side of the legs for support. Instructions: From a standing position, sit down on the floor with legs crossed, without using your hands, knees, forearms, or side of the legs for support. Rise back to a standing position without using any support (this is the goal). If support is needed, the scoring is as follows: Deduct 1 point for each hand, knee, or forearm used going down and up The maximum score is 10. A score of 8 or more is considered ideal. 3. Waist-to-Height Ratio Objective: Assess body fat distribution, metabolic health and risk.Goal: The smaller the ratio between your waist and height, the better. Instructions: Measure your height in centimeters (cm). Measure your waist circumference at the narrowest point between the ribs and the hips in centimeters. Calculate the ratio: Waist Circumference (cm) / Height (cm).  4. Grip StrengthObjective: Assess hand and forearm strength. Correlates with cardiovascular disease risk.Goal: The larger the number, the better Instructions: Use a grip strength dynamometer. Stand upright and hold the dynamometer at your side. Squeeze the dynamometer as hard as you can. Record the highest reading in lb after 3 attempts in each hand 5. Sit and Reach (YMCA)  Objective: Measure flexibility of the lower back and hamstrings.Goal: The further you reach, the better Instructions: Video Sit on the floor with your legs extended straight out in front of you, with approximately 10-12 inches of distance between your feet Place a second tape measure at the 15” mark between the ~5-6 inch mark of the first tape measure (think like you’re making a “T” or a “+” with both tape measures), the zero should be closest to you. Heels should be resting on the first tape measure.   Place one hand on top of the other, palms facing down, and reach forward as far as possible along the measuring line. Hold the stretch for 1-2 seconds. Measure the distance reached by the fingertips. Repeat twice and record the best distance. 6. One-Leg Stand / Balance TestObjective: Measure balance and lower body strength.Goal: The longer you can balance, the better Instructions: Stand with their eyes shut and on one leg with the other leg bent at the knee and lifted off the ground and free floating. Hold this position as long as possible without touching the raised leg to the ground, using external support, or touching their other leg. Record the time you can hold the position in seconds. Perform the test on both legs and record the times.  7. Reaction Time Test Objective: Measure quickness of response to a stimulus.Goal: The smaller the reaction time, the better Instructions: Download the App “Reaction Time & Reflex Test.’ Click on the Game “Lights Out” Start a new test. Place your thumb or finger on the screen to start the countdown. All 5 lights will illuminate. As soon as the lights turn out pull your finger or thumb off the screen. Repeat 5 times and take the best score of the 5 tests. This will be the lowest number.   If you want more comprehensive baseline testing, we got you covered. Blueprint Labs empowers you with data to take control of your health. Blood PanelsTest either 60 or 115 biomarkers with a comprehensive suite of blood and urine tests designed for deep analysis and insights (basic, advanced). MicroplasticsThe world’s first at-home microplastics blood test, enabling you to screen for most common commercial plastics with just a finger-prick (link). Speed of AgingFind out how old you really are, and learn the biological age and health of 11 critical organ systems and how fast or slow your aging (link).

When I started doing Blueprint in 2021, measuring food and supplements for accuracy of label claims and toxins was a top priority. We needed to know for accuracy purposes, was I consuming what we thought? As you may guess, what we found was a sad reality of today’s food and supplement systems.  Very few label claims are correct and our food system is toxic. It’s even worse than you think. Some companies are oblivious to these things because they don’t test. Others know and knowingly misrepresent. We learned to never believe anything companies say and to only trust lab reports.  If you want to see what I’m talking about, we reviewed 10 top chocolate brands for heavy metals. Watch the video. You can’t unsee it. And neither can we. After learning how dirty, toxic and misrepresented food and supplements are, we started sourcing our own ingredients and testing them ourselves. After all, I was trying to become the healthiest person on the planet and how could that happen unless we can get the exact amount of something and control the toxin load.  We got really good at this process. After Blueprint went viral, the most common comment we got was “I want to do this! But it’s too complicated. Make it easy.” I thought about this for a long time because I’d never imagined building a food and supplement company and I was busy building the world’s first mass market brain interface.  But, as I had learned in optimizing my personal health, no one in the world had built an entire family of healthy and clean foods; enough to satisfy an entire day's calories and nutrition. This is what I wanted someone else to have done, but of course, you usually have to build what you want to exist in the world.  Over the past year, I think we’ve built the cleanest and healthiest family of foods and supplements in the world. To make this more concrete, last month alone we spent over $50,000 testing foods for toxins and purity. That has to be unprecedented.  I previously ate Blueprint because it was the most evidence based health protocol in the world. Now I eat Blueprint also because I’m terrified of the food system, don’t really trust anyone else, and know from seeing the reports that Blueprint is verifiably clean. Our third-party labs conduct comprehensive analyses of ingredients and products to ensure potency and purity. These tests cover a wide range of components, including macronutrients, vitamins, minerals, and standardized botanicals. The labs also screen for potential contaminants such as GMOs, heavy metals, microorganisms, pathogens, pesticides, phthalates, and aflatoxins. Additionally, they check for the presence of allergens and perform other product-specific tests as needed. This thorough examination process helps maintain the quality and safety of our food and supplement products. Finding the right suppliers and getting these systems in place has not been easy. For example, sometimes it took us over a year to find a supplier that would meet our standards. Sometimes vendors wouldn’t even consider working with us because of our required testing. Vendors' reluctance to embrace clean label initiatives often stems from the extra costs associated with testing for contaminants and sourcing healthier ingredients, which can impact profit margins. We select vendors who embrace these initiatives because transparency and health-conscious products benefit everyone involved. It’s been a whoooooole thing. But we’ve been incredibly successful. Again, I think it is the best in the world.  One thing we’ve wanted to test but haven’t been able to is microplastics. We called over 50 labs and only found one that has a very limited microplastics testing ability. Far short of what we actually need. So we’re kind of flying blind, like all 8 billion of us on earth, when it comes to microplastics. The world just hasn’t set up infrastructure to test microplastics at scale. We are speaking with a few labs to see if we can stand up the infrastructure to make this happen.  The challenge is that microplastics are everywhere. At the bottom of the ocean. On top of Mount Everest. In the rain. In our drinking water, clothes, mouthguards, skin care products and in our brains.  Without having data, we don’t know where best to focus our personal efforts to reduce microplastic exposure. For example, does 50% of the microplastics in our body come from drinking water? Or plastic water bottles?  Or take out food?  Or are microplastics in clothing the worst offender? We are at the very beginning of understanding.  We are transitioning to non-plastic packaging. In this process, we face challenges due to plastic's prevalence at every level of the global supply chain and a lack of clear alternatives. While sustainable options often mean shorter shelf-life and higher costs, we're committed to finding innovative packaging solutions that balance personal exposure, environmental concerns and are economically viable. The good news is the industry is moving in this direction and several companies are working on new approaches. Know we’re just as eager to get rid of plastic as you are. In the meantime, I do feel comforted eating all of my Blueprint supplements and food that it’s already among the cleanest in the world.  To take matters into our own hands, we are excited to announce the world’s first mass market microplastics test. It’s a finger prick test and tells you the kinds of microplastics circulating in your bloodstream and how you compare to others. Science begins with counting.  With this data, we will work together as a community to see if we can make headway in learning together how we can reduce our microplastic load. We may find that drinking water is the worst offender and would help us concentrate our efforts. We may find certain therapies, such as donating plasma, are great in lowering concentrations. Science begins with counting and when we have the data, we can make systematic progress. We’re trying to do three things for you: 1. Every calorie 2. Every test 3. Every friend  If you say yes to health, we want to provide you with everything you need for optimal nutrition. We want you to have the confidence that you’re getting the best in the world. We want you to have data on the health status of your body via blood work, microplastics, your speed of aging and your organ ages. We want you to have routine cancer screening via MRI and get biomarkers on your brain health plus other vital organs. We want you to get the same value as some of the most expensive executive longevity programs in the world ($50,000-$150,000) at a fraction of the cost. That’s what we’ve built for you.  Note that we’ve only been at this for a year. What we’ve accomplished in this time is staggering. The Blueprint team and I consume everything you do. We are with you on this journey. One step at a time we will get ourselves ever closer to Don’t Die. Wishing you the best. Bryan  Disclaimer: this blog is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.  

  MRI saved my life. It may save yours too.    Context: My brain was silently dying and I wouldn’t have known had it not been for a routine MRI.  A few years ago, a routine MRI showed that I have internal jugular vein stenosis (IJVS). This means I have genetically narrow jugular veins which restricted blood flow from my brain to my body which is very bad for the brain. My bad posture was making it ever worse. After the MRI found this - that I’ve had my entire life but never diagnosed any other way - I was able to do physical therapy and improve my posture and muscle that corrected for better blood flow. I also corrected for my sleep position and posture when I look at my phone or work on a computer. These things dramatically improved the health of my brain via the reduction of white matter hyper-intensities.    MRIs see things that physical appearance hides, blood work struggles to pick up, and for which no symptoms exist. Sometimes saving our lives.    And while MRI scans are great, most protocols only measure a handful of things.    I’ve learned this first hand. Over the past few years, I’ve become the most biologically measured person in history and MRI is among the most valuable measurements I routinely do. I may have now spent more time in an MRI than any living person. This has taught me a lot about why MRI is valuable.   If you want to be proactive about your health you can do this annually. Longitudinal monitoring is the best way to detect changes early.   + Detect potential cancer in the early stages to help ensure the best outcome + Identify life-threatening problems such as tumors, aneurysms, and more + Screens for 500 conditions & health of 13 organs+ Decode the biological age of your brain + Provide a comprehensive measurement profile of your joints and spine, informing lifestyle and therapies + Create your digital twin so that you now have a baseline to follow what is or is not working for your improved health.  Here are my latest MRI results:✔ No detectable cancer✔ Brain age: 42 (I’m 48)✔ Hippocampi are in the 72nd percentile ✔ Brain volume top 73rd percentile✔ Brain inflammation: less than 80% of my age group✔ Brain gray matter: top 84th percentile✔ Brain white matter: top 80th percentile lesion free✔ Muscle mass: 100th percentile ✔ Fat in Muscles: 100th percentile ✔ Visceral fat: 100th percentile ✔ Subcutaneous fat: 100th percentile ✔ LV/Brain ratio is 1% (better than 64% of my peers). Lateral Ventricles become enlarged with age as the brain tissue shrinks. This is a general marker of aging and of dementia and AD. MRI is widely used and well-known to be safe. You can also add a low-dose chest CT to screen for potential lung cancer, emphysema, lung bullaes, cysts and more The dream for the future is that all of us will have routine MRI scans to find problems at their earliest stages and help us proactively manage our health. Bryan Disclaimer: this blog is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

We've partnered with TrueMed to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA) on the Blueprint Store.  If qualified, you can buy our products with pre-tax dollars, resulting in net savings of 30-40%. How It Works Here’s a step-by-step guide to walk you through one-time and subscription orders. For one-time orders:  Go to the Blueprint store  Add your favorite Blueprint products to your cart (choosing “one-time purchase”)  At checkout, under Payment, choose “TrueMed - Pay with HSA/FSA” Enter your HSA/FSA card details Take the 1-minute survey to determine your eligibility Once eligibility is confirmed, you’ll receive a confirmation email with your Blueprint product details For subscription orders:  Go to the Blueprint store  Add your favorite Blueprint products to your cart (choose  “Subscribe & Save”)  At checkout, pay with your normal credit or debit card After you complete your purchase, you’ll receive a confirmation email with a survey inside Take the 1-minute survey to determine your eligibility In a few business days, the TrueMed Concierge will contact you about eligibility Once you’re approved, TrueMed will reimburse you via your HSA/FSA providerPlease note, you must check out as a guest to use TrueMed. If you are logged into a payment method, such as ShopPay, you might not see the TrueMed optionYou can find these steps on our HSA / FSA information page.

  Can my joints age backwards? I received a cutting-edge therapy aimed at achieving age 18 joints, at a clinic owned by Tiger Woods & Justin Timberlake. I had 300 million young Swedish bone marrow mesenchymal stem cells injected into my shoulders, hips, and joints. The aim: joints to match my total bone mineral density, which is in the top 99.8% for 30-year-olds Wait, what’s going on? Our joints, such as knees and hips, break down with age, resulting in pain, stiffness, and movement restriction. While I do not have any major joint problems, I do experience small aches and pains. We are exploring if we can repair normal age-related damage, restore vitality, and preventatively lessen future deterioration.   The therapy I had 300 million bone marrow-derived mesenchymal stem cells (MSCs) injected into six joints over two days: knees, shoulders, and hips. This therapy was part of a Cellcolabs Clinical trial in the Bahamas, with the MSCs manufactured by Cellcolabs and the injections performed by Dr. Steven Sampson of Physical Longevity .   MeasurementPrior to the therapy, we completed a comprehensive baseline analysis of each joint using MRI and musculoskeletal ultrasound. The findings were: Bilateral shoulder labral degenerative tears with paralabral cysts. Tendinosis in bilateral supraspinatus rotator cuffs with subacromial bursitis. Bilateral knee chondromalacia patella with left knee mild to moderate effusion/bursitis. Bilateral hip gluteus medius tendinosis and bilateral hip Cam impingement syndrome.   These findings sound bad but they are normal wear and tear you'd find in an active 46-year-old.   Therapy planWe aim to improve function, mobility, and athletic performance, eliminate aches and pains, and potentially regenerate tissue to prevent future degeneration. What we did: Intra-articular injections in bilateral shoulders, hips, and knees. Bilateral supraspinatus rotator cuff and bursa injections. Right shoulder anterior labrum injection. Bilateral hip gluteus medius tendon injections.   The cells were prepared and shipped from Sweden, cryopreserved with liquid nitrogen, checked for viability at the point of care, and injected under ultrasound guidance by Dr. Steven Sampson for proper deployment under strict protocol. My blood was sent to Sweden to analyze inflammation, hormone, immune, and DNA longevity biomarkers for post-treatment analysis.   How did it go?  I was pretty sore for three days after the injections. It was hard to walk and use my joints. By day 4, I started loosening up and by day 10 I was back to my normal routine.    Follow up measurement The trial involves follow-up visits at 1, 3, 6, and 12 months. Aside from the study protocol, we will measure my joints again with MRI in six months to assess whether the therapy works. The twelve-month time point will also be informative.   My dad The big idea here: what if every twelve months we did a series of therapies (ourselves, parents and children), that repaired the damage (and injuries) that occurred that year. Time passes, but our bodies remain the same age.  Wouldn’t that be cool. Bryan Disclaimer: this blog is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

  My six-month longevity gene therapy results are in…  In September 2023, I traveled to Roatan, an island off the coast of Honduras, to receive follistatin gene therapy. Humans currently have a maximum lifespan of roughly 120 years. However, gene therapies have the potential to help break through that barrier. Follistatin gene therapy ranks 7th among lifespan studies, extending mouse lifespan by over 30%. My 71-year-old father also received the gene therapy. His life expectancy is 68 based on how he’s lived life. He’s awaiting his six-month results. His ferocious want for life is energizing.   This gene therapy is not FDA approved, so I traveled to Roatán, where there is a special economic zone for these kinds of treatments.    Me as a kid: A kid born with the effects of this gene therapy: My results:  My speed of aging has dropped to 0.64 (a personal best). I now celebrate my birthday every 19 months.   My muscle mass is up by 7% (already in the 99th percentile)   My follistatin levels increased by 160% (2 weeks post-injection)   Don’t Die is humanity's only objective. Gene therapies might bring us a step closer.    Sleep, diet, and exercise remain foundational. These next-generation therapies further bolster our chances of being the first generation that has the choice of saying yes to continuous tomorrows.    Bryan Disclaimer: this blog is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.