Blueprint Self-Experimentation Study

Apply now: https://blueprintbryanjohnson.typeform.com/study

Hi Fellow Explorers,

"Make Blueprint easy to do" is the top request we’ve received. We’ve now done it. The basics are ready for you.

Blueprint is competing for the most nutritious food program in history. It is designed for adults of all ages and genders. We’re already cost-competitive with fast food. And there are many more exciting items coming soon.

We have enough inventory from our first production run to supply 2,500 people for 90 days. You can apply today for one of these slots.

Blueprint items included for this initial group are the following:

  • Longevity Mix, a 6 oz drink mix
  • Eight supplements:
    • Essential Capsules
    • Essential Softgel
    • NAC+Ginger+Curcumin
    • RYR+Garlic
  • Nutty Pudding (w/ nuts+blueberries), a meal
  • Extra virgin olive oil, 750 mL (50 Tbsp)

Product details [1]

Together, these items provide you elite levels of nutrition. They equal 410 calories. As a participant, you’ll eat what you normally would each day minus ~400 calories you’re getting from the Blueprint stack.

Together, there are 67 “interventions” in these products. An intervention and its dose is selected based upon randomized controlled trials and strong epidemiological evidence.

We normally think about food as a “cost”. Blueprint is a new relationship of how we think about what we put into our body; it’s an investment in your health. The monthly amount is an investment of $333.

With this basic stack, we are competing for the most nutritious food program in history. It is designed for adults of all ages and genders. We’re already cost-competitive with fast food. And there are many more exciting products coming soon.

As a self-experimentation participant, you are invited to invest in measuring your biomarkers. Measurement can be expensive and is not always affordable or accessible for everyone, so we’ve created three tiers of measurement options: $0, ~$800 and ~$1,600. You will choose a level when applying to be a participant.

Participants will be uploading biomarker data into a decentralized clinical trial system that will enable us to do group-level data analysis, which we will share. We will not be analyzing your individual biomarkers or providing any guidance. That will remain the role of your doctor. The objective is to quantify changes in certain biomarkers when a large group of us regularly consume Blueprint basics for 90 days.

This expands Blueprint from an n=1 to n=2,500. It creates the foundation for many other things we can do together including adding more interventions and doing more robust quantification.

You can apply today. We will then assemble the participant cohort and begin notifying participants the week of January 15th.

Once selected, you’ll be invited to participate in a discord community [2] where we will work together to help everyone identify cost effective testing providers around the world. This is the first step in Blueprint becoming a bulk buying club for all things health and wellness.

It’s important that participants complete baseline measurements by the end of January to begin consuming Blueprint products in February.

We are toiling vigorously (while getting 100% sleep score) to scale capacity so that we can reliably provide monthly subscriptions to all. If you’re not part of this initial 2,500 group, we will be opening it up to others as fast as possible.

We’re also adding more food items to satisfy a day’s worth of calories and nutrition (see [3] for our roadmap and nutrition details). We are mindful that if you want Blueprint to be your single source of food we’ll need to satisfy your needs of variety, texture and taste. We’re on it.

Blueprint is about health and wellness. Also, it’s a secret plan to kickstart our evolution from Homo Sapiens to Homo Evolutis.

In summary:

  • You can apply to be a self-experimentation participant now.
  • Participants will be notified the week of January 15th.
  • Baseline measurements to be completed by the end of January.
  • Begin consuming Blueprint in February.
  • You’ll try to maintain similar sleep, diet and exercise habits during the 90 days to avoid confounding results. This first step is focusing on measuring nutritional changes.
  • Participants can decide to invest either $0, ~$800 or ~$1,600 into measuring biomarkers.
  • Participants will upload their biomarker data into a decentralized clinical trial software so that the Blueprint team can perform data analysis which will be shared.
  • Those who are not selected for this initial group will have the opportunity to start Blueprint in the next month or so as we increase our production capacity.
  • More Blueprint items will be introduced shortly that will satisfy an entire day’s caloric and nutritional needs.
  • Blueprint is competing for the most nutritious food program in history.
  • We are currently in the process of figuring out international availability. We can ship to the below 26 countries, however, the clinical trial system we’re using for data management needs to comply with the respective country's data and privacy laws. We are evaluating the path to complete that compliance in each country. For now, if you are in one of the countries below and are interested in participating, please apply and we will do our best to see if we can get the system up and running for your country.
    • Currently shipping to the following countries: Australia, Austria, Belgium, Canada, Czech Republic, Denmark, Finland, France, Germany, Hong Kong SAR China, Ireland, Israel, Italy, Japan, Malaysia, Netherlands, New Zealand, Norway, Poland, Portugal, Singapore, South Korea, Spain, Sweden, Switzerland, United Arab Emirates, United States, and United Kingdom.

Other housekeeping items:

  • Vibe: we want this to be fun and feel like a game we’re playing together.
  • We’re building this on the fly with you so expect there to be constant improvements, and also bumps.
  • We are a very small team and won’t be able to answer general inquiries about your health or topics generally.
  • You will be engaged, responsive, and attentive to this effort.

Apply now:https://blueprintbryanjohnson.typeform.com/study

  1. Product detail: https://blueprint.bryanjohnson.com
  2. Blueprint Community: https://discord.gg/CZHTFBjq6h
  3. Blueprint food road map through Q2 2024: https://cdn.shopify.com/s/files/1/0772/3129/2701/files/Product_Nutrition_Facts.pdf?v=1704325409

Blood Draw Information

The blood draw process is the same regardless of your location, and it is simple:

Purchase your blood work here, and Randox will contact you to finalize the process.

Randox provides two draw options depending on your location.

  1. Visit a local clinic
  2. At-home kit

For the majority of people, you will visit a local clinic to have your blood drawn. If there are no local clinics near you, you will receive a kit in the mail, and a phlebotomist will visit you.

  • USA: Most people will receive an at-home kit and phlebotomist.
  • UK: Most people will visit a local Randox clinic.
  • Australia: Most people will see a local partner clinic.
  • Germany: Most people will receive an at-home kit and phlebotomist.
  • Canada: Most people will visit a local partner clinic.

The regulations vary across countries so it is nuanced. No matter the circumstances Randox will make sure each of you has a viable solution to have your blood drawn.

If you live in the UK, Randox has many clinic locations in all major cities. When purchasing your blood work online, you will automatically be directed to a scheduling link where you can schedule your blood draw immediately. If you can't find a location near you, email Randox for assistance in locating a site (customerservice@randoxhealthla.com). If you purchased your blood work a few days ago and did not see a scheduling portal, don't worry, Randox will personally contact you. If you need to contact Randox for any other blood draw issue please don’t hesitate to reach out customerservice@randoxhealthla.com. They have a fantastic team and are working to get to everyone as quickly as possible.

If you receive a test kit at home from Randox, be patient. Based on your location, Randox will contact you with further instructions. If you are in a location where there are no Randox clinics, your test kit will include a QR code, which you will use to schedule your mobile phlebotomist appointment (at no extra cost).

Essentials - $495 — Includes two complete panels at Day 1 & Day 90 — 3 vials of blood

  • CBC Platelets
  • Glucose
  • HbA1C
  • hsCRP
  • GFR
  • BUN
  • Creatinine (serum)
  • Cystatin C
  • ALP
  • AST
  • ALT
  • GGT
  • Total bilirubin
  • Albumin
  • CPK
  • PSA - Total
  • Total Cholesterol
  • LDL Cholesterol
  • HDL Cholesterol
  • Triglycerides
  • SHBG
  • Testosterone
  • Estradiol
  • Thyroid Free T3
  • Thyroid Free T4
  • Thyroid TSH
  • Total IgE
  • Ferritin
  • Calcium serum
  • Copper serum
  • Magnesium serum
  • Potassium serum
  • Vit C serum
  • Vit D 25-OH serum
  • B12 total serum
  • Folate serum
  • Zinc serum
  • Sodium serum

Extended - $995 — Includes two complete panels at Day 1 & Day 90 — 8 vials of blood

  • CBC Platelets
  • Glucose
  • HbA1C
  • hsCRP
  • GFR
  • BUN
  • Creatinine (serum)
  • Cystatin C
  • ALP
  • AST
  • ALT
  • GGT
  • Total bilirubin
  • Albumin
  • CPK
  • PSA - Total
  • Total Cholesterol
  • LDL Cholesterol
  • HDL Cholesterol
  • Triglycerides
  • SHBG
  • Testosterone
  • Estradiol
  • Thyroid Free T3
  • Thyroid Free T4
  • Thyroid TSH
  • Total IgE
  • Ferritin
  • Calcium serum
  • Copper serum
  • Magnesium serum
  • Potassium serum
  • Vit C serum
  • Vit D 25-OH serum
  • B12 total serum
  • Folate serum
  • Zinc serum
  • Sodium serum
  • Selenium serum
  • Vit E alpha tocopherol serum
  • Apolipoprotein A-1
  • Apolipoprotein B
  • CA-125 (Age 50+ women only)
  • NT-proBNP (AGE 60+ ONLY)
  • C peptide
  • Insulin
  • Homocysteine
  • IGF-1
  • Lipoprotein (a)
  • Urate
  • Amylase
  • Lipase
  • Beta Carotene
  • Lead whole blood
  • Magnesium rbc
  • Mercury whole blood
  • Vitamin A serum
  • Methymalonic Acid (MMA)

If you did not purchase a kit through Raxdox and are planning to have your primary care physician order these tests, please send the list above to your physician and DO NOT purchase a kit through Randox.

Once you have completed the draw, please upload a PDF copy of your results to your participant portal (launching early February).

FAQ

What health tracker should I use?

You can use your existing wearable. We’ve also negotiated discounts on your behalf with Whoop and Oura. You can use your existing scale or buy Withings ($99 or $179) and the Withings blood pressure cuff (optional, $97) if blood pressure is a topic of concern.

We are working out the details of our data management system and how we will be integrating the data from these various devices. It’s possible that we’ll pull all data from Apple Health which acts as a repository for your health data. More soon.

You: I love data and want more of it!

We understand that sentiment. Below are some additional measurements you can do. Note however, these additional measurements may or may not be able to be uploaded to our clinical trial software and or included in the group analysis. We can evaluate interest and update the community.

  • Pace of Aging DNA Methylation. $270 (w/ Blueprint discount) includes two tests, before and after.
  • DEXA scan for bone mineral density if risk of osteopenia or osteoporosis (or EchoLite REMS bone ultrasound for fracture risk, arguably more accurate and no radiation)
  • DEXA scan for fat, visceral fat and muscle (or AMRA MRI body composition scan, no radiation and arguably more accurate, but a lot more expensive)
  • NAD test (discount “BP5000") $174

Will you collect my measurements like blood draws?

No, we will give you instructions on what to gather but you will be responsible for collecting your measurements.

How will you know we’re eating Blueprint?

It is an honor system. We may also add some check ins via the trial software.

At what age can I participate?

17+

Where in the world can people do this?

We are currently in the process of figuring out international availability. We can ship to the below 26 countries, however, the clinical trial system we’re using for data management needs to comply with the respective country's data and privacy laws. We are evaluating the path to complete that compliance in each country. For now, if you are in one of the countries below and are interested in participating, please apply and we will do our best to see if we can get the system up and running for your country.

Currently shipping to the following countries: Australia, Austria, Belgium, Canada, Czech Republic, Denmark, Finland, France, Germany, Hong Kong SAR China, Ireland, Israel, Italy, Japan, Malaysia. Netherlands, New Zealand, Norway, Poland, Portugal. Singapore, South Korea, Spain, Sweden, Switzerland, United Arab Emirates, United States, and United Kingdom.

Will you analyze my data for me?

No. We will analyze the data on the cohort level (everyone) and will share that.

Will my data be public?

Your data will be anonymized and grouped together with everyone else’s. Your personal data and identity will not be revealed.

Can I share my data / progress online?

Yes, we love that.

What will be a part of the baseline measurements?

  • Questionnaires
  • Body composition
  • Bloodwork
  • Vitamins and Minerals
  • Wearable devices (i.e. Whoop, Oura, etc.)

Can I use my blood draw data from 3 months or 3 years ago instead of getting new labs?

As long as it's within the last three months you can use it.