Essential Microbiome

GUT BARRIER • MICROBIOME • DIGESTION

A 2-in-1 postbiotic combining pasteurized Akkermansia and tributyrin to support digestion, microbiome balance, and healthy aging.*

Size: 30-day supply

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Nutrition Facts +
Supplement FactsServing SizeServings Per ContainerAmount Per Serving% Daily Value1 Liquid Capsule30Butyrate Triglycerides (from fermented sources)300 mgAkkermansia Muciniphila (pasteurized) 10 Billion TFU50 mg† Daily Value not establishedOther Ingredients: Hypromellose (delayed release veggie capsule), microcrystalline cellulose, medium chain triglycerides, silicon dioxide, rice extract blend and carrot concentrate.
Description +

Supports gut barrier, microbiome diversity, and metabolic health with 2 longevity actives for gut health*

Pasteurized Akkermansia: a keystone postbiotic strain that supports gut barrier integrity and microbiome balance*

Tributyrin: a butyrate-releasing compound that supports gut lining and a healthy inflammatory response*

Postbiotic formula supports gut health directly, without relying on live bacteria to survive or colonize*

Delayed-release technology delivers each ingredient where it supports gut health best*


Precision doses backed by research (no pixie dusting)

Third-party tested for purity and heavy metals

How to Use +

Take 1 capsule in the morning with food. No refrigeration necessary.

30 servings per container. 1 delayed-release veggie capsule per serving.

Bryan's recommendation: 

Essential Microbiome is the final step in the Blueprint pre-, pro-, and postbiotic gut health stack:

Formulated from longevity research

Trust data, not opinions

  • GUT BARRIER

    • Supports mucus layer health*
    • Reinforces gut barrier integrity*
    • Builds resilience from the inside*
  • MICROBIOME

    • Supports beneficial bacteria associated with a healthy gut*
    • Promotes a balanced microbiome*
    • Promotes a healthy inflammatory response*
  • DIGESTION

    • Supports healthy gut function*
    • Nourishes gut wall*
    • Supports digestive wellness*
Translucent Essential Microbiome capsule with pink blend on a stone surface — Blueprint longevity supplement
Translucent Essential Microbiome capsule with pink blend on a stone surface — Blueprint longevity supplement
Translucent Essential Microbiome capsule with pink blend on a stone surface — Blueprint longevity supplement
PRECISION NUTRITION

Clinically-backed ingredients

Based on decades of science that has been validated across ages, genders, and genetic backgrounds.

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3RD PARTY TESTEDRESEARCH-BACKEDPRECISION DOSING
Two magenta Essential Microbiome capsules in a clear glass dish beside water on stone — Blueprint longevity supplement

How to Use

Daily protocol

Take 1 capsule in the morning with food. No refrigeration necessary.

Blueprint vs Others

How we measure up

BLUEPRINT
OTHERS
Transparent third-party testing
Consumed by Bryan Johnson
Clinically-backed ingredients
Study-level precision doses
No fillers
Blueprint Bryan Johnson quality standards laboratory chemistry equipment

A peer-reviewed study found that...

89% of surveyed supplements were mislabeled.*

Blueprint publishes their third-party test results so you're in control of what goes in your body.

*Study of 57 sports enhancement herbal supplements published in JAMA Network Open (2023). COAs are property of Blueprint and are not to be used without Blueprint's consent.

Frequently asked questions

Blueprint Essential Microbiome contains two longevity actives for gut health: pasteurized Akkermansia (10B TFU), a keystone postbiotic strain, and tributyrin (300mg), a butyrate-releasing compound.
Blueprint Essential Microbiome is best consumed in the morning with food. No refrigeration required.
Bryan Johnson includes supplements to support his microbiome as part of his daily longevity protocol. Blueprint Essential Microbiome is the final step in the pre-, pro-, and postbiotic approach within the Blueprint supplement range, completing the gut health stack:
- Prebiotics: Metabolic Protein, Raw Macadamias, and Blueberry Nut Mix provide dietary fiber
- Probiotics: Essential Capsules, which contain Lactobacillus Acidophilus
- Postbiotics: Essential Microbiome delivers pasteurized Akkermansia and tributyrin
Yes. The ingredients in Blueprint Essential Microbiome undergo rigorous third-party testing for purity and heavy metals.
The recommended dosage for Blueprint Essential Microbiome is 1 delayed-release veggie capsule daily with food to support gut barrier integrity, microbiome balance, and healthy aging.*
A postbiotic delivers the beneficial end results that probiotics and prebiotics are trying to produce, without requiring your gut to do the work. Blueprint Essential Microbiome's pasteurized Akkermansia is a postbiotic.
Akkermansia is a keystone postbiotic strain found in the mucus layer of healthy guts. Blueprint Essential Microbiome uses pasteurized Akkermansia, which has been shown in clinical trials to support healthy blood sugar, insulin sensitivity, and cholesterol levels already within normal range.*
Tributyrin is a butyrate-releasing compound used in Blueprint Essential Microbiome. Unlike direct butyrate supplements, tributyrin survives digestion and releases butyrate directly in the colon, where it supports gut lining integrity and a healthy inflammatory response.*