Kate Tolo is Starting a Female Protocol

I am about to become the most measured woman in history. And I am honestly pretty nervous.

The goal is to build a female-specific protocol based on female data.

This is going to be time-intensive, willpower-intensive, and very constrictive. But I am mostly so excited and very hopeful that we will uncover really rudimentary and yet powerful insights that will be practical for women.

I previously did Bryan's protocol intensely for 90 days (based on population-level data for males and females) and saw amazing results for improving my health generally.

This is next-level.

I'm going all in with $2 million per year and a full-time medical team. Just like with Bryan, we will share all of the learnings for free.

Why I'm starting the female protocol

When we look to randomized controlled trials (RCTs) for women's health, we're often looking for studies that don't exist. It leaves half the population guessing.

The FDA removed women from clinical trials for 16 years (1977 to 1993). So while RCTs are viewed as the gold standard, they underserve women.

With n=1 science, we can measure 1 body to find clues about what may actually work.

For women, this is long overdue.

What I'm doing

Bryan could map his baseline in a week or 2. Mine will take months. That's because the female body isn't static. It changes throughout the menstrual cycle.

Total cholesterol alone can swing ~19% across a single cycle. What else changes? How does this impact everything else?

We're measuring everything:

• 1,900 biomarkers across blood, urine, stool, vaginal microbiome, and more
• at 4 time points per cycle: follicular, ovulation, luteal, and menstruation
• across multiple months, while I do the same thing every day: nutrition, sleep, exercise.

For context, over the past 5 years, Bryan has collected 1.5 billion data points on his body. With how much measurement technology has improved, I'll likely exceed that in a short time.

Once we've mapped my baseline, I'll start the interventions.

We want to answer questions like:

• can fertility be improved?
• should women cold plunge, fast, or follow a different sauna protocol?
• can PMS symptoms be alleviated?
• what keeps a cycle regular?
• does the body need more iron, magnesium, or protein at specific phases?
• should recovery protocol change by phase?
• what's the earliest detectable signal of perimenopause? And can it be slowed?

I also have endometriosis. So do 10% of all women. We'll be looking closely at that, too.

I'll share everything: good, bad, ugly, what works, what fails.

My intent is that women have someone in their court looking after their health.