Poor sleep damages your brain. Here’s how to avoid it…

Written by: Bryan Johnson

Published on: December 17, 2024

Poor sleep damages your brain. Here’s how to avoid it…

Written by: Bryan Johnson

Published on: December 17, 2024

Hi Friend,

Sleep deprivation is brain damage.

Young healthy participants showed a 20% increase in S-100B levels following a single night of sleep deprivation, the same following brain traumatic injury.

My S-100B levels are top 1% optimal, reflecting my devotion to ideal sleep.

What is S-100B?
S-100B is a calcium-binding protein that plays a crucial role in various cellular processes, including cell growth. Elevated levels of S-100B are associated with numerous pathological conditions, including:
❌ Brain trauma
❌ Neurodegenerative disorders
❌ Cancer
❌ Depression and anxiety

How does sleep affect S-100B?
The damage happens by disrupting the blood-brain barrier, allowing the protein S-100B to leak into the bloodstream, which at high levels, triggers inflammation and becomes toxic to brain cells, potentially leading to neuronal death.

What is an ideal S-100B level?
My S-100B is perfect, be sure yours is too.

My recent result is 63.1 ng/L with a range of 20.6 - 103.7 which is 99th percentile optimal.

The goal for S-100B is midrange. Elevated levels signal your brain is under stress. Low levels could mean the brain isn’t properly repairing itself. Middle range allows brain recovery and resilience.

3 Tips to Keep Your S-100B in Check

Elevated serum S-100B levels are common markers of brain inflammation due to injury, poor sleep or bad diet
Prioritizing quality sleep is one of the best ways to reduce S-100B and protect your brain
Focus on deep sleep as this is when the brain goes through its most reparative processes
Follow my sleep routine and become a professional sleeper

Be well,

Bryan

Sources:
https://pubmed.ncbi.nlm.nih.gov/24470708/
https://www.nature.com/articles/s41598-020-75618-0
https://www.spandidos-publications.com/10.3892/or.2017.5922
https://pmc.ncbi.nlm.nih.gov/articles/PMC6405260/